Multidrug resistant Salmonella enterica serovar typhi.

Nepal is having a series of enteric fever epidemics over the last decade1,2 with changing resistance patterns.3 The fi rst report of multidrug resistant Salmonella enterica serovar Typhi in Nepal was published in 1991.4 In the following years, with the introduction of fl uoroquinolones in the treatment, nalidixic acid-resistant strains associated with reduced susceptibility to fl oroquinolones have been continuously reported from Nepal and trend of resistance is increasing.1,5 Subsequently, occasional isolation of highly fl uoroquinolone resistant and third generation cephalosporins resistant S. paratyphi A and S. typhi strains has also been reported from Nepal6,7 and other developing countries such as India and Bangladesh.